Senior Scientist Virology
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Senior Scientist Virology

King of Prussia, PA

The Center for Breakthrough Medicines is on track to be the largest single-site cell and gene therapy contract development and manufacturing organization in the world. Our comprehensive service offering accelerates speed to market through supply chain disruption mitigation strategies, end-to-end program management expertise and unique platform technology with the ability to follow a molecule from idea to commercialization. CBM’s integrated approach provides high quality and consistent end-to-end manufacturing capability including: Process and Analytical Development; Plasmid DNA production; Viral Vector Production of Lentivirus; AAV and Adenovirus; Testing and Analytics; Autologous, Allogeneic and Gene-edited Cell Therapy Bioprocessing; and Cell banking. CBM’s horizontal and vertical integration provides one source throughout a product’s life cycle.

CBM’s mission is to accelerate the delivery and affordability of lifesaving and life-changing therapies from discovery to market by offering a complete solution for the development and commercialization of cell and gene therapies.

CBM is located just outside of Philadelphia in the Heart of Cellicon Valley on The Discovery Labs campus set on 300 acres with 2.4 million square feet of life sciences lab and manufacturing space, allowing clients to scale their development and manufacturing needs without ever having to change sites, while providing employees a true community campus experience focused exclusively on life sciences.

The Discovery Labs is a Global Platform Company inclusive of CBM, The Discovery Labs Properties, UniteIQ incubator labs, and The Colony, a unique investment and resource model enabling groundbreaking therapies to be brought to life.

Summary

The Discovery Labs Center for Breakthrough Medicine is seeking a solid candidate to join our Virology team as a technical lead at Analytical Development and Testing organization. 

Responsibilities

  • Demonstrate the highest moral standard and ethical integrity.
  • Responsibility for method development, validation, and transfer activities
  • Incorporating automation into new method development and adapting existing methods for automation.
  • Capable of making decisions independently and troubleshoot/optimize experiments and procedures.
  • Flexible to support multiple research projects as the AD organization grows.
  • Writing test methods, SOPs, reports, analytical sections of works and performing and coordinating testing to support analytical development, process development and manufacturing investigations across functional groups.
  • Transfers methods to partner functions and represent the Analytical Virus Assay team in cross-functional meetings.
  • Accurately capturing of data in a timely manner, including maintenance of detailed records in compliance with applicable regulations, safety, and environmental requirements is expected.

Qualifications

  • Ph.D. with 1+ years of directly cell therapy or gene therapy related experience OR MS with 3+ years of directly related experience
  • With knowledge of molecular virology
  • Experience in development of viral assays for cell therapy or gene therapy products, such as infectivity, tittering, replication competent recombinant viruses to be used in support of assay development work.
  • Experience with molecular biology and biochemical techniques such as qPCR, RT-PCR, ddPCR, ELISA, RNA/DNA purification, cell culture and flow cytometry (not all required).
  • Experience with viruses (e.g. AAV/Lentivirus/Adenovirus) is desired
  • Demonstrate ability to maintain lab execution records and perform data analysis.
  • Strong technical writing and presentation skills
  • Other responsibilities will include automation analytical methods.
  • Experience in gene therapy and GMP environment is strongly desirable

Compensation: TBD

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