CBM

Full Time EE - Onsite

Center for Breakthrough Medicines is on track to be the largest single-site cell and gene therapy contract development and manufacturing organization in the world. Our comprehensive service offering accelerates speed to market through supply chain disruption mitigation strategies, end-to-end program management expertise and unique platform technology with the ability to follow a molecule from idea to commercialization. CBM’s integrated approach provides high quality and consistent end-to-end manufacturing capability including: Process and Analytical Development; Plasmid DNA production; Viral Vector Production of Lentivirus; AAV and Adenovirus; Testing and Analytics; Autologous, Allogeneic and Gene-edited Cell Therapy Bioprocessing; and Cell banking. CBM’s horizontal and vertical integration provides one source throughout a product’s life cycle.

CBM’s mission is to accelerate the delivery and affordability of lifesaving and life-changing therapies from discovery to market by offering a complete solution for the development and commercialization of cell and gene therapies.

CBM is located just outside of Philadelphia in the Heart of Cellicon Valley on The Discovery Labs campus set on 300 acres with 2.4 million square feet of life sciences lab and manufacturing space, allowing clients to scale their development and manufacturing needs without ever having to change sites, while providing employees a true community campus experience focused exclusively on life sciences.

Summary

This role is responsible for supporting the planning, executing, analyzing, reporting on, and presenting on experiments related to Cell Therapy Process Development and Intensification. This position works closely with the Cell Therapy technical leader, technical teams within Process Development, and the client to understand and deliver against defined objectives. This role authors and reviews technical protocols and reports, and procedures. The ideal candidate should have a track record of demonstrated success as well as personal attributes including initiative, independent thinking, solution-oriented and collaboration skills.

Responsibilities

• Associate bench scientist, capable of understanding a study plan including execution
• Support team in the management of work, including sourcing of materials, use of equipment and space, time management, problem solving, and risk identification/escalation to meet objectives
• Supports the technical leader in the design and implementation of cell therapy process development strategies
• Hands-on laboratory work in executing, and optimizing of cell therapy unit operations
• Support technology transfers from development to pilot scale and ultimately into vector manufacturing
• Works closely with clients and technical team on appropriate process and characterization studies to enable manufacturing
• Authors and development and process protocols, reports, and batch records
• Supports analytical method development and testing as needed

Qualifications

• BS in Chemical Engineering, Biology, or similar life sciences degree with knowledge of cell therapy technologies and experience in fundamental laboratory techniques (academic or industry)
• Ability to follow procedures with attention to detail, and successfully execute experiments at the bench
• Comfortable in a fast-paced environment
• Strong communication skills (e.g., clear and concise) and a team player
• Critical and logical thinking with ability to analyze problems, identify alternative solutions, and implement recommendations for resolution
• Self-motivated and flexible, able to prioritize, multi-task, and work in a fast-paced & demanding environment
• Able to understand and interpret data/information and its practical application