King of Prussia, PA
2 Years Ago
Center for Breakthrough Medicines is on track to be the largest single-site cell and gene therapy contract development and manufacturing organization in the world. Our comprehensive service offering accelerates speed to market through supply chain disruption mitigation strategies, end-to-end program management expertise and unique platform technology with the ability to follow a molecule from idea to commercialization. CBM’s integrated approach provides high quality and consistent end-to-end manufacturing capability including: Process and Analytical Development; Plasmid DNA production; Viral Vector Production of Lentivirus; AAV and Adenovirus; Testing and Analytics; Autologous, Allogeneic and Gene-edited Cell Therapy Bioprocessing; and Cell banking. CBM’s horizontal and vertical integration provides one source throughout a product’s life cycle.
CBM’s mission is to accelerate the delivery and affordability of lifesaving and life-changing therapies from discovery to market by offering a complete solution for the development and commercialization of cell and gene therapies.
CBM is located just outside of Philadelphia in the Heart of Cellicon Valley on The Discovery Labs campus set on 300 acres with 2.4 million square feet of life sciences lab and manufacturing space, allowing clients to scale their development and manufacturing needs without ever having to change sites, while providing employees a true community campus experience focused exclusively on life sciences.
This role is responsible for planning, performing, analyzing, summarizing, reporting, and presenting experimental results related microbial fermentation and purification process development. The ideal candidate will help design and startup a nucleic acid process development laboratory to support plasmid DNA production and mRNA synthesis. The scientist will develop a platform microbial fermentation process and subsequent downstream purification at both the laboratory and pilot scale. Experience in Microbial Fermentation Upstream and/or Purification Process development and optimization is a requirement. This position works closely with internal and external stakeholders to deliver technical documents such as reports, protocol, and data reviews.
The primary responsibility of this candidate is to develop a scalable end to end plasmid production platform. The scientist will also collaborate with both external and internal stakeholders to support ancillary activities such as analytical testing, cell banking, process scaleup, and technical transfer. In addition to the technical skills required (plasmid process development, scale-up, and production), this role authors and reviews technical protocols and reports, drafts batch records and SOPs. The ideal candidate will successfully demonstrate upstream and downstream process development, scaleup, and analytics. Personal attributes including independent thinking, having a self-starter mindset, and strong collaboration skills are required. The final level of this position will be set according to candidate experience and qualifications.
TBD