Bioprocessing Technician
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Bioprocessing Technician

King of Prussia, PA

The Center for Breakthrough Medicines is on track to be the largest single-site cell and gene therapy contract development and manufacturing organization in the world. Our comprehensive service offering accelerates speed to market through supply chain disruption mitigation strategies, end-to-end program management expertise and unique platform technology with the ability to follow a molecule from idea to commercialization. CBM’s integrated approach provides high quality and consistent end-to-end manufacturing capability including: Process and Analytical Development; Plasmid DNA production; Viral Vector Production of Lentivirus; AAV and Adenovirus; Testing and Analytics; Autologous, Allogeneic and Gene-edited Cell Therapy Bioprocessing; and Cell banking. CBM’s horizontal and vertical integration provides one source throughout a product’s life cycle.

CBM’s mission is to accelerate the delivery and affordability of lifesaving and life-changing therapies from discovery to market by offering a complete solution for the development and commercialization of cell and gene therapies.

CBM is located just outside of Philadelphia in the Heart of Cellicon Valley on The Discovery Labs campus set on 300 acres with 2.4 million square feet of life sciences lab and manufacturing space, allowing clients to scale their development and manufacturing needs without ever having to change sites, while providing employees a true community campus experience focused exclusively on life sciences.

The Discovery Labs is a Global Platform Company inclusive of CBM, The Discovery Labs Properties, UniteIQ incubator labs, and The Colony, a unique investment and resource model enabling groundbreaking therapies to be brought to life.

Position Summary:

The Bioprocessing Technician will be responsible for performing routine cGMP manufacture of viral vectors supporting gene therapy. The incumbent will be responsible for operating upstream and downstream equipment for adherent and suspension systems and performing production support activities while maintaining compliance to cGMP standards.  This position will onboard the inaugural manufacturing staff for the stand up for a new organization. We are looking for a hard-working solution-oriented team player to join our family. This position requires multi-tasking, wearing many hats and has the potential to evolve into a supervisor role.

Primary Responsibilities:

  • Work cross-functionally in a hands-on capacity to operate single use bioreactors and ÄKTA chromatography/TFF equipment, Ultracentrifugation, Final Fill Finish, prepare media and buffer solutions, and clean/sterilize equipment as required. 
  • Ensure work is completed in compliance with controlled documentation (SOPs, batch records, forms, etc.) and all applicable guidelines, safety policies and procedures are followed. 
  • Assist in maintaining the GMP status of the manufacturing facility to ensure inspection readiness at all times.
  • Assist in the resolution of manufacturing deviations and troubleshooting of process and equipment problems. 
  • Train new technicians and write and complete SOPs for equipment and processes. 
  • Assist in validation activities for the suites and equipment. 

Education & Experience

  • Bachelor’s degree in biological science(s) field or related engineering is preferred but not required. 
  • A minimum of 2-10 years of experience in cGMP biological manufacturing. Viral vector manufacturing or other gene therapy is highly preferred.
  • General knowledge of cGMP regulations. 
  • Strong written and verbal communication skills, with excellent teamwork aptitudes 
  • Detail-oriented; takes on ownership of the work; innovative with a focus on continuous improvements. 
  • Able to adhere to all safety and company regulations. 
  • Able to accommodate a flexible work schedule when needed to support business demands.

Compensation: TBD

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